P3
PARTNER 3 Trial: Safety and Effectiveness of the SAPIEN 3 Transcatheter Heart Valve in Low Risk Patients With Aortic Stenosis
AI Description
To establish the safety and effectiveness of the Edwards SAPIEN 3 Transcatheter Heart Valve (THV) in patients with severe, calcific aortic stenosis who are at low operative risk for standard aortic valve replacement.
- Who can join
- child, adult, older adult
- Participants
- 1000
- Expected completion
- 2029-12
- Funded by
- industry
Conditions studied
Aortic Stenosis
What is being tested
- DEVICE: SAPIEN 3 THV
- PROCEDURE: SAVR
What it measures
- All-cause Mortality, All Stroke, and Rehospitalization (Valve-related or Procedure-related and Including Heart Failure), Number of patients that had any of these events, 1 year
Centers Participating
These centers are participating in this study. Reach out to them directly to learn more.
AdventHealth Orlando
Orlando, FL
Albany Medical Center
Albany, NY
Allegheny General Hospital
Pittsburgh, PA
Ascension Saint Thomas Hospital
Nashville, TN
Ascension Seton Medical Center Austin
Austin, TX
Atrium Health Carolinas Medical Center
Charlotte, NC
Banner – University Medical Center Phoenix
Phoenix, AZ
Baptist Memorial Hospital-Memphis
Memphis, TN
Barnes-Jewish Hospital
Saint Louis, MO
Baylor Scott & White The Heart Hospital – Plano
Plano, TX
Brigham and Women's Hospital
Boston, MA
Cedars-Sinai Medical Center
Los Angeles, CA
Central Maine Medical Center
Lewiston, ME
CHI Health Nebraska Heart
Lincoln, NE
Cleveland Clinic
Cleveland, OH
Corewell Health William Beaumont University Hospital
Royal Oak, MI
Emory University Hospital
Atlanta, GA
Endeavor Health Evanston Hospital
Evanston, IL
Hartford Hospital
Hartford, CT
HCA Florida JFK Hospital
Atlantis, FL
Henry Ford Health (Detroit)
Detroit, MI
Hillcrest Medical Center
Tulsa, OK
Hoag Hospital (Newport Beach)
Newport Beach, CA
Hospital of the University of Pennsylvania
Philadelphia, PA
HSHS St. John's Hospital
Springfield, IL
Inova Fairfax Medical Campus
Falls Church, VA
Intermountain Medical Center
Murray, UT
Kaiser Permanente San Francisco Medical Center
San Francisco, CA
Kaleida Health
Buffalo, NY
Lankenau Medical Center
Wynnewood, PA
M Health Fairview University of Minnesota Medical Center (East Bank)
Minneapolis, MN
Mayo Clinic (Rochester, Minnesota)
Rochester, MN
Medical City Heart Hospital (Dallas)
Dallas, TX
Mills-Peninsula Medical Center
Burlingame, CA
Morristown Medical Center
Morristown, NJ
Mount Carmel East
Columbus, OH
Mount Sinai Medical Center
Miami Beach, FL
Newark Beth Israel Medical Center
Newark, NJ
NewYork-Presbyterian Hospital
New York, NY
Northwestern Memorial Hospital
Chicago, IL
Novant Health Presbyterian Medical Center
Charlotte, NC
NYU Langone Health
New York, NY
Ochsner Medical Center – New Orleans
New Orleans, LA
Oklahoma Heart Hospital (Oklahoma City)
Oklahoma City, OK
Providence St. Vincent Medical Center
Portland, OR
Ronald Reagan UCLA Medical Center
Los Angeles, CA
Rush University Medical Center
Chicago, IL
Saint Luke’s Hospital of Kansas City
Kansas City, MO
Sentara Norfolk General Hospital
Norfolk, VA
Stanford Health Care
Stanford, CA
Sutter Medical Center, Sacramento
Sacramento, CA
The Christ Hospital
Cincinnati, OH
The Queen’s Medical Center
Honolulu, HI
UAB Hospital
Birmingham, AL
UCHealth Medical Center of the Rockies
Loveland, CO
UF Health Shands Hospital
Gainesville, FL
UNC Health Rex (Raleigh)
Raleigh, NC
University Hospital
Madison, WI
University Medical Center
Charlottesville, VA
University of Iowa Health Care
Iowa City, IA
University of Washington Medical Center
Seattle, WA
WellSpan York Hospital
York, PA
Registry entry updated 2026-01-14
Deciding whether to join a study is your choice, and you can ask a study team questions before you decide anything.
If you would rather we did it with you, call us on (656) 206-4686.