ReChord
Randomized Trial of the Neochord DS1000 System Versus Open Surgical Repair
AI Description
The objective of this trial is to assess the safety and effectiveness of the study device in subjects with degenerative mitral valve disease receiving a mitral valve repair without cardiopulmonary bypass (treatment group) when compared to subjects receiving mitral valve repair using standard surgical techniques with cardiopulmonary bypass (control group).
- Who can join
- adult, older adult
- Participants
- 585
- Expected completion
- 2027-01
- Funded by
- industry
Conditions studied
Mitral Valve Insufficiency
What is being tested
- DEVICE: NeoChord DS1000
- DEVICE: Surgical Mitral Valve Repair
What it measures
- Proportion of subjects free of Grade II, III or IV mitral regurgitation, mitral valve replacement or mitral valve reintervention in the treatment group when compared to subjects in the control group., 1 year
- Proportion of subjects free of Major Adverse Events (MAEs) in the treatment group when compared to subjects in the control group., Post-operative Day (POD) 30
Centers Participating
These centers are participating in this study. Reach out to them directly to learn more.
Ascension Saint Thomas Hospital
Nashville, TN
Baylor Scott & White The Heart Hospital – Plano
Plano, TX
Franciscan Health Indianapolis
Indianapolis, IN
MedStar Washington Hospital Center
Washington, DC
Mercy General Hospital (Sacramento)
Sacramento, CA
Stanford Health Care
Stanford, CA
The Johns Hopkins Hospital
Baltimore, MD
The Mount Sinai Hospital
New York, NY
University of Michigan Health System
Ann Arbor, MI
UPMC Harrisburg
Harrisburg, PA
UPMC Presbyterian Shadyside
Pittsburgh, PA
Winchester Medical Center
Winchester, VA
Registry entry updated 2026-04-08
Deciding whether to join a study is your choice, and you can ask a study team questions before you decide anything.
If you would rather we did it with you, call us on (656) 206-4686.