ALLIANCE: Safety and Effectiveness of the SAPIEN X4 Transcatheter Heart Valve
AI Description
The objective of this study is to establish the safety and effectiveness of the Edwards SAPIEN X4/X4S Transcatheter Heart Valve (THV) in subjects with symptomatic, severe, calcific aortic stenosis (AS).
- Who can join
- child, adult, older adult
- Participants
- 1234
- Expected completion
- 2037-01
- Funded by
- industry
Conditions studied
Aortic Stenosis, Severe
What is being tested
- DEVICE: SAPIEN X4 THV
- DEVICE: SAPIEN X4S
What it measures
- Non-hierarchical composite of death and stroke, The number of patients that died or had a stroke, 1 year
Centers Participating
These centers are participating in this study. Reach out to them directly to learn more.
Allegheny General Hospital
Pittsburgh, PA
Ascension Alexian Brothers Medical Center
Elk Grove Village, IL
Ascension Saint Thomas Hospital
Nashville, TN
Ascension St. Vincent Heart Center
Carmel, IN
Ascension Via Christi (Wichita)
Wichita, KS
Atrium Health Carolinas Medical Center
Charlotte, NC
Barnes-Jewish Hospital
Saint Louis, MO
Baylor Scott & White The Heart Hospital – Dallas
Dallas, TX
Baylor Scott & White The Heart Hospital – Plano
Plano, TX
Brigham and Women's Hospital
Boston, MA
California Pacific Medical Center (Van Ness Campus)
San Francisco, CA
Cedars-Sinai Medical Center
Los Angeles, CA
CentraCare – St. Cloud Hospital
Saint Cloud, MN
Cleveland Clinic
Cleveland, OH
Emory University Hospital
Atlanta, GA
Endeavor Health Evanston Hospital
Evanston, IL
Hartford Hospital
Hartford, CT
HCA Houston Healthcare Medical Center
Houston, TX
Henry Ford Health (Detroit)
Detroit, MI
Hillcrest Medical Center
Tulsa, OK
Hoag Hospital (Newport Beach)
Newport Beach, CA
Kaiser Permanente Los Angeles Medical Center
Los Angeles, CA
Kaiser Permanente San Francisco Medical Center
San Francisco, CA
Kaleida Health
Buffalo, NY
Mayo Clinic (Rochester, Minnesota)
Rochester, MN
Medical City Heart Hospital (Dallas)
Dallas, TX
MedStar Union Memorial Hospital
Baltimore, MD
Memorial Hermann-Texas Medical Center
Houston, TX
Montefiore Einstein Hospital (Moses Campus)
Bronx, NY
Morristown Medical Center
Morristown, NJ
Naples Comprehensive Health (NCH)
Naples, FL
NewYork-Presbyterian Hospital
New York, NY
Northwestern Memorial Hospital
Chicago, IL
Novant Health Presbyterian Medical Center
Charlotte, NC
Oklahoma Heart Hospital (Oklahoma City)
Oklahoma City, OK
Piedmont Atlanta Hospital
Atlanta, GA
Providence St. Patrick Hospital
Missoula, MT
Providence St. Vincent Medical Center
Portland, OR
Robert Wood Johnson University Hospital
New Brunswick, NJ
Rush University Medical Center
Chicago, IL
Saint Luke’s Hospital of Kansas City
Kansas City, MO
Scripps Memorial Hospital La Jolla
La Jolla, CA
Sentara Norfolk General Hospital
Norfolk, VA
Silver Cross Hospital
New Lenox, IL
Stanford Health Care
Stanford, CA
The Christ Hospital
Cincinnati, OH
The University of Kansas Health System
Kansas City, KS
The Valley Hospital
Paramus, NJ
TriStar Centennial Medical Center
Nashville, TN
UC Davis Medical Center
Sacramento, CA
UCHealth Medical Center of the Rockies
Loveland, CO
University of Washington Medical Center
Seattle, WA
UPMC Harrisburg
Harrisburg, PA
Vanderbilt University Medical Center
Nashville, TN
Registry entry updated 2026-09-03
Deciding whether to join a study is your choice, and you can ask a study team questions before you decide anything.
If you would rather we did it with you, call us on (656) 206-4686.