TRIPLACE
Global Multicenter Registry on Transcatheter TRIcuspid Valve RePLACEment
AI Description
The field of transcatheter tricuspid valve replacement (TTVR) is rapidly emerging and data on this topic are scarce. Particularly, little is known about which patients are at greatest risk of procedural complications, such as the timing and onset of conduction disturbances necessitating permanent pacemaker implantation, and how such patients are managed. On this background, the TRIPLACE Registry - an investigator-initiated global multicenter registry - is aimed at better understanding the safety and efficacy of orthotopic TTVR.
- Who can join
- adult, older adult
- Participants
- 800
- Expected completion
- 2028-12
- Funded by
- other
Conditions studied
Tricuspid Regurgitation
What is being tested
- DEVICE: Transcatheter Tricuspid Valve Replacement
What it measures
- Freedom from device-related complications, Freedom from device-related complications will be determined by assessing the number of participants with procedural, peri-procedural and device-related complications, 30 days after the index procedure
- Reduction in Tricuspid Regurgitation Severity, Tricuspid Regurgitation measured by transthoracic echocardiography. Assessment of MI severity according to current guidelines (ESC/EACTS and ACC/AHA) for valvular heart disease. Tricuspid Regurgitation is measured by transthoracic echocardiography in accordance with current guidelines (ESC/EACTS and ACC/AHA) for valvular heart disease. Mean tricuspid regurgitation severity will be determined using the following scale: 0=none/trace; 1=mild; 2=moderate; 3=severe; 4=massive; 5=torrential. Change from baseline tricuspid regurgitation severity score 30 days after baseline will be assessed, 30 days after the index procedure
Working with
The Cleveland Clinic, University Hospital, Bordeaux, University of Toronto
Centers Participating
These centers are participating in this study. Reach out to them directly to learn more.
Registry entry updated 2026-09-15
Deciding whether to join a study is your choice, and you can ask a study team questions before you decide anything.
If you would rather we did it with you, call us on (656) 206-4686.