ARTIST
ARTIST: Aortic Regurgitation Trial Investigating Surgery Versus Trilogy™
AI Description
To demonstrate non-inferiority of the Trilogy Transcatheter Heart Valve (THV) System compared with surgical aortic valve replacement (SAVR) for treatment of subjects with clinically significant native aortic regurgitation (AR)
- Who can join
- child, adult, older adult
- Participants
- 1016
- Expected completion
- 2036-02
- Funded by
- industry
Conditions studied
Aortic Insufficiency, Aortic Regurgitation, Aortic Valve Insufficiency
What is being tested
- DEVICE: SAVR
- DEVICE: Transcatheter Aortic Valve Replacement (TAVR) using Trilogy THV System
What it measures
- All stroke, Number of patients that had stroke, 12 months
- All-Cause Mortality, all-cause mortality at 12 months, 12 months
- unplanned cardiac rehospitalization, Number of patients who had unplanned cardiac rehospitalization, 12 months
Centers Participating
These centers are participating in this study. Reach out to them directly to learn more.
Abbott Northwestern Hospital
Minneapolis, MN
Ascension St. Vincent Heart Center
Carmel, IN
Barnes-Jewish Hospital
Saint Louis, MO
Beth Israel Deaconess Medical Center
Boston, MA
Cedars-Sinai Medical Center
Los Angeles, CA
Cleveland Clinic
Cleveland, OH
Deborah Heart & Lung Center
Browns Mills, NJ
Emory University Hospital Midtown
Atlanta, GA
HCA Florida North Florida Hospital
Gainesville, FL
Henry Ford Health (Detroit)
Detroit, MI
Houston Methodist Hospital
Houston, TX
Intermountain Medical Center
Murray, UT
Kaleida Health
Buffalo, NY
Lankenau Medical Center
Wynnewood, PA
Los Robles Regional Medical Center
Thousand Oaks, CA
Massachusetts General Hospital
Boston, MA
Mayo Clinic (Rochester, Minnesota)
Rochester, MN
MedStar Washington Hospital Center
Washington, DC
Mills-Peninsula Medical Center
Burlingame, CA
Morton Plant Hospital (Clearwater)
Clearwater, FL
MUSC Health
Charleston, SC
OhioHealth Riverside Methodist Hospital
Columbus, OH
OHSU Hospital
Portland, OR
Piedmont Atlanta Hospital
Atlanta, GA
Robert Wood Johnson University Hospital
New Brunswick, NJ
Saint Luke’s Hospital of Kansas City
Kansas City, MO
Scripps Memorial Hospital La Jolla
La Jolla, CA
Sentara Norfolk General Hospital
Norfolk, VA
The Christ Hospital
Cincinnati, OH
UChicago Medicine AdventHealth Hinsdale
Hinsdale, IL
University of Michigan Health System
Ann Arbor, MI
University of Washington Medical Center
Seattle, WA
Registry entry updated 2026-09-17
Deciding whether to join a study is your choice, and you can ask a study team questions before you decide anything.
If you would rather we did it with you, call us on (656) 206-4686.