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REdo tranScatheter Aortic Valve Replacement for Transcatheter aOrtic Valve failuRE
AI Description
The purpose of this study is to generate clinical evidence on valve safety and performance in subjects treated by redo Transcatheter Aortic Valve Replacement (TAVR).
- Who can join
- adult, older adult
- Participants
- 225
- Expected completion
- 2027-11
- Funded by
- industry
Conditions studied
Aortic Stenosis
What is being tested
- DEVICE: Edwards TAV
- DEVICE: Medtronic TAV
What it measures
- Primary Outcome Measure, 30-day redo TAVR success defined as correct positioning of a single redo prosthetic heart valve into the proper anatomic location, intended performance of the valve (mean gradient \<20mmHg, peak velocity \<3 m/s, Doppler velocity index (DVI) ≥0.25, aortic regurgitation (AR) \< moderate), and freedom from all-cause mortality, coronary obstruction, unplanned coronary revascularization, and surgery or intervention related to the device, Early (30-days)
- Primary Outcome Measure, a composite endpoint of 1-year freedom from all-cause mortality, all stroke, or any re-hospitalization for valve or redo TAVR procedure-related causes, Late (1-year)
Centers Participating
These centers are participating in this study. Reach out to them directly to learn more.
Tampa General Hospital
Tampa, FL
Abbott Northwestern Hospital
Minneapolis, MN
Allegheny General Hospital
Pittsburgh, PA
Ascension Saint Thomas Hospital
Nashville, TN
Ascension Seton Medical Center Austin
Austin, TX
Ascension St. Vincent Heart Center
Carmel, IN
Ascension Via Christi (Wichita)
Wichita, KS
Atrium Health Wake Forest Baptist Medical Center
Winston-salem, NC
Aurora St. Luke's Medical Center
Milwaukee, WI
Baylor St. Luke's Medical Center
Houston, TX
Brigham and Women's Hospital
Boston, MA
Catholic Medical Center
Manchester, NH
CentraCare – St. Cloud Hospital
Saint Cloud, MN
Corewell Health Butterworth Hospital
Grand Rapids, MI
Froedtert Hospital
Milwaukee, WI
Hartford Hospital
Hartford, CT
Henry Ford Health (Detroit)
Detroit, MI
Houston Methodist Hospital
Houston, TX
Inova Fairfax Medical Campus
Falls Church, VA
Jersey Shore University Medical Center
Neptune, NJ
Kaleida Health
Buffalo, NY
Lankenau Medical Center
Wynnewood, PA
Lehigh Valley Hospital–Cedar Crest
Allentown, PA
Los Robles Regional Medical Center
Thousand Oaks, CA
MaineHealth Maine Medical Center (Portland)
Portland, ME
Massachusetts General Hospital
Boston, MA
Mayo Clinic (Rochester, Minnesota)
Rochester, MN
MedStar Union Memorial Hospital
Baltimore, MD
MedStar Washington Hospital Center
Washington, DC
Memorial Hermann-Texas Medical Center
Houston, TX
MercyOne Des Moines Medical Center
Des Moines, IA
Methodist Hospital
San Antonio, TX
Montefiore Einstein Hospital (Moses Campus)
Bronx, NY
Morton Plant Hospital (Clearwater)
Clearwater, FL
NYU Langone Health
New York, NY
OhioHealth Riverside Methodist Hospital
Columbus, OH
Oklahoma Heart Hospital (Oklahoma City)
Oklahoma City, OK
Orlando Health
Orlando, FL
Parkview Regional Medical Center
Fort Wayne, IN
Penn State Health Holy Spirit Medical Center
Camp Hill, PA
Providence Sacred Heart Medical Center & Children's Hospital
Spokane, WA
Providence St. Patrick Hospital
Missoula, MT
Providence St. Vincent Medical Center
Portland, OR
Saint Luke’s Hospital of Kansas City
Kansas City, MO
Sandra Atlas Bass Heart Hospital at North Shore University Hospital
Manhasset, NY
Sentara Norfolk General Hospital
Norfolk, VA
St. Francis Hospital & Heart Center
Roslyn, NY
Stanford Health Care
Stanford, CA
Sutter Medical Center, Sacramento
Sacramento, CA
The Christ Hospital
Cincinnati, OH
The Johns Hopkins Hospital
Baltimore, MD
The Mount Sinai Hospital
New York, NY
The University of Kansas Health System
Kansas City, KS
The University of Vermont Medical Center
Burlington, VT
The Valley Hospital
Paramus, NJ
TriStar Centennial Medical Center
Nashville, TN
Tucson Medical Center
Tucson, AZ
UAB Hospital
Birmingham, AL
UCHealth Medical Center of the Rockies
Loveland, CO
University Hospitals Cleveland Medical Center
Cleveland, OH
University Medical Center
Charlottesville, VA
University of Iowa Health Care
Iowa City, IA
University of Michigan Health System
Ann Arbor, MI
UPMC Presbyterian Shadyside
Pittsburgh, PA
Yale New Haven Hospital
New Haven, CT
Registry entry updated 2026-05-28
Deciding whether to join a study is your choice, and you can ask a study team questions before you decide anything.
If you would rather we did it with you, call us on (656) 206-4686.